Akribio Corp. developed PRO7 for chemists to simultaneously conduct up to 7 independent reactions of entirely different conditions. Temperature control, including heating, heat-ramping, cooling, and cool-ramping, is critical for chemists to get optimal outcomes while using PRO7 to conduct multiple reactions simultaneously. Meanwhile, PRO7 is an instrument having a very compact footprint of 18"x19". Akribio has successfully developed proprietary and patented technologies that are able to control the temperatures as well as the thermal modes of up to 7 independent reactions in a compact space.

Each PRO7 consists of 7 independent reactors; the associate temperature control is briefly described as follows:

In terms of hardware, a reactor includes

• a well, made of anodized aluminum alloy,
• off-the-shelf standard glass vessels, i.e., round-bottom flask of 100, 50, 25, and 10mL,
• an independent temperature controller consisting of a build-in CPU and a set of memory chips,
• separate thermo sensors detecting both Tr (temperature of reaction mixture) and Tj (temperature of the jacket of well),
• a heating mechanism of electricity, and
• a cooling mechanism including the following options:
• - thermal-electric,
• - adiabatic expansion,
• - cryogenic bath, and
• - combination of above.

In terms of software, the CPU executes a set of algorithms of multiple control loops for

• dynamically raising or dropping the temperature of the well,
• adjusting the difference between Tr and Tj while compensating heat losses to ambient,
• in-situ calibrating and adjusting the thermal flow between the reaction mixture and the well.

This way, each reactor can thus perform the followings:

• reaching the Set Point (SP) of Tr or Tj with minimum overshoot < 1oC,
• holding the Present Value (PV) of Tr or Tj with minimum damping < 0.3oC, and
• ramping the Present Value (PV) of Tr or Tj up and/or down with specified speeds from one SP to another SP.

Akribio offers end-users with both standard and customized specifications of temperature control. A user can select the necessary attributes of the temperature control, i.e., range of SP and ramping rate, number of thermal stages, duration of continuous operations, fault-proof, time-temperature profile recording, etc., to specifically meet his/her needs.